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Structure of 453565-91-8
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3-Cyano-5-(trifluoromethoxy)benzoic acid features a conjugated aromatic core bearing electron-withdrawing cyano and trifluoromethoxy groups, enhancing its utility in medicinal chemistry. The carboxylic acid functionality enables direct coupling or derivatization under standard conditions, while the fluorinated substituent imparts metabolic stability and modulates lipophilicity. This structure supports integration into bioactive scaffolds requiring strong dipole moments and enhanced membrane permeability.
3-Cyano-5-(trifluoromethoxy)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and functionalized aromatic scaffolds. Its dual functionality—cyano and carboxylic acid groups—facilitates diverse transformations including amidation, esterification, and cyclization reactions. The trifluoromethoxy substituent enhances metabolic stability and lipophilicity, while the compound exhibits good bench stability and ease of purification, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: