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CS-W001157 4
Total: USD 88.00

4-Ethylcyclohexanol

  • CAS No. 4534-74-1

  • Cat. No. CS-0152471
  • Purity≥98%
  • MDL No.MFCD00001450

*For research and further manufacturing use only, not for direct human use.

4-Ethylcyclohexanol|CS-0152471

Structure of 4534-74-1

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General Information

  • CAS No. 4534-74-1
  • Cat. No. CS-0152471
  • Purity ≥98%
  • MDL No. MFCD00001450
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆O
  • Molecular Weight 128.21
  • Synonym(s) Ethylcyclohexanol
  • SMILES CCC1CCC(CC1)O

Description

4-Ethylcyclohexanol features a cyclohexanol core with an ethyl substituent at the para position, delivering enhanced hydrophobicity and steric bulk. This structural configuration improves thermal stability and solubility in nonpolar solvents, enabling efficient integration into polymer intermediates and specialty resins.

Application

4-Ethylcyclohexanol serves as a versatile cyclic alcohol intermediate in organic synthesis, offering enhanced steric and electronic properties compared to unsubstituted cyclohexanol. Its bench-stable nature and tolerance to common functional group manipulations enable reliable use in oxidation, esterification, and coupling reactions. The ethyl substituent provides controlled conformational bias, making it valuable for stereocontrolled transformations and the construction of complex carbocyclic scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • v. Braun; Mannes; Reuter Chemische Berichte, 1933 , vol. 66, p. 1499,1501
  • Route2

    References

    • Abbina, Srinivas; Bian, Shi; Oian, Casey; Du, Guodong ACS Catalysis, 2013 , vol. 3, # 4 p. 678 - 684
  • Route3

    References

    • Yan, Ning; Yuan; Dykeman, Ryan; Kou, Yuan; Dyson, Paul J. Angewandte Chemie - International Edition, 2010 , vol. 49, # 32 p. 5549 - 5553

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.9475
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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