Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-Fluoro-4-methylaniline

  • CAS No. 452-77-7

  • Cat. No. CS-W013514
  • Purity≥98%
  • MDL No.MFCD00007762

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-methylaniline|CS-W013514

Structure of 452-77-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 452-77-7
  • Cat. No. CS-W013514
  • Purity ≥98%
  • MDL No. MFCD00007762
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FN
  • Molecular Weight 125.15
  • Synonym(s) 4-Amino-2-fluorotoluene
  • SMILES NC1=CC=C(C)C(F)=C1

Description

3-Fluoro-4-methylaniline features a fluorine atom at the meta position and a methyl group at the para position relative to the amine, delivering enhanced electron density and improved solubility in organic media. This substitution pattern enables selective coupling reactions under mild conditions, facilitating efficient access to functionalized anilines for pharmaceutical intermediates and agrochemical synthesis.

Application

3-Fluoro-4-methylaniline serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-fluoro and para-methyl substituents provide enhanced metabolic stability and modulate electronic properties for target engagement. The compound exhibits bench stability, facilitates straightforward purification, and functions effectively in amide couplings, Suzuki-Miyaura reactions, and electrophilic substitutions common to API development workflows.

Synthesis

  • Route1

    References

    • Khan, Faiz Ahmed; Dash, Jyotirmayee; Sudheer; Gupta, Rakesh Kumar Tetrahedron Letters, 2003 , vol. 44, # 42 p. 7783 - 7787
  • Route2
    • null|null
      88-72-2
    • ~%
    • In-stock
      3-Fluoro-4-methylaniline|CS-W013514
      452-77-7

    References

    • Cell Pathways, Inc. Patent: US6020379 A1, 2000 ;
  • Route3

    References

    • Attina, Marina; Cacace, Fulvio; de Petris, Giulia Journal of the American Chemical Society, 1985 , vol. 107, p. 1556 - 1561

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H227-H300-H312+H332-H315-H319-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.71632
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3-Fluoro-4-methylaniline sigma3-Fluoro-4-methylaniline manufacturer3-Fluoro-4-methylaniline price3-Fluoro-4-methylaniline structure3-Fluoro-4-methylaniline SDSbuy 3-Fluoro-4-methylaniline3-Fluoro-4-methylaniline supplier3-Fluoro-4-methylaniline uses3-Fluoro-4-methylaniline molecular weightprice of 3-Fluoro-4-methylaniline3-Fluoro-4-methylaniline chemical name formula of 3-Fluoro-4-methylaniline
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label