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CS-W001157 4
Total: USD 88.00

5-Fluoro-2-methylaniline

  • CAS No. 367-29-3

  • Cat. No. CS-W013512
  • Purity≥98%
  • MDL No.MFCD00007764

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methylaniline|CS-W013512

Structure of 367-29-3

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General Information

  • CAS No. 367-29-3
  • Cat. No. CS-W013512
  • Purity ≥98%
  • MDL No. MFCD00007764
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FN
  • Molecular Weight None
  • Synonym(s) Fluoromethylaniline7
  • SMILES C1=C(C(=CC=C1F)C)N

Description

5-Fluoro-2-methylaniline features a fluorine atom at the 5-position and a methyl group at the 2-position, creating a uniquely activated aromatic system. This electron-rich scaffold enables efficient coupling reactions in pharmaceutical synthesis, particularly in constructing substituted anilines for kinase inhibitors and bioactive heterocycles. The compound exhibits excellent stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, streamlining its integration into multi-step synthetic sequences.

Application

5-Fluoro-2-methylaniline serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-methyl and meta-fluoro substituents provide directed functionalization opportunities and enhance metabolic stability in target molecules. The compound exhibits good bench stability and facilitates efficient derivatization under mild conditions, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.71632
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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