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Structure of 451447-23-7
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4-Chloroquinolin-7-amine delivers a strategically positioned chloro substituent and amine functionality within a quinoline scaffold, enabling direct integration into transition-metal-catalyzed couplings and downstream derivatization. This bench-stable, moisture-tolerant heterocycle serves as a pivotal building block for advanced pharmaceutical intermediates and functional materials.
4-Chloroquinolin-7-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 7-position via palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates efficient C–N and C–C bond formation under standard conditions, while the quinoline core provides inherent stability and π-system compatibility for drug-like scaffolds. The compound exhibits excellent bench stability and is readily purified by column chromatography, making it ideal for iterative synthesis campaigns targeting kinase inhibitors and other heterocyclic therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: