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CS-W001157 4
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5-Chloro-2-formylbenzoic acid

  • CAS No. 4506-45-0

  • Cat. No. CS-W019485
  • Purity≥97%
  • MDL No.MFCD06739601

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-formylbenzoic acid|CS-W019485

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General Information

  • CAS No. 4506-45-0
  • Cat. No. CS-W019485
  • Purity ≥97%
  • MDL No. MFCD06739601
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClO₃
  • Molecular Weight 184.58
  • Synonym(s) 5-CHLORO-2-FORMYL-BENZOIC ACID
  • SMILES OC(=O)C1=C(C=O)C=CC(Cl)=C1

Description

5-Chloro-2-formylbenzoic acid features a formyl group ortho to a carboxylic acid and a chloro substituent at the para position, enabling direct conjugation in heterocyclic synthesis. This electron-deficient aromatic scaffold integrates readily into complex scaffolds under mild conditions.

Application

5-Chloro-2-formylbenzoic acid serves as a versatile bifunctional building block for the synthesis of heterocyclic scaffolds and bioactive molecules. The ortho-formyl and carboxylic acid groups enable sequential functionalization, facilitating cyclizations, amide couplings, and metal-catalyzed transformations. Its bench-stable nature and compatibility with common protecting group strategies support efficient multi-step synthesis in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   1.8507
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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