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CS-W001157 4
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2-Bromo-5-(trifluoromethyl)pyrimidine

  • CAS No. 69034-09-9

  • Cat. No. CS-0101604
  • Purity≥97%
  • MDL No.MFCD14702304

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-(trifluoromethyl)pyrimidine|CS-0101604

Structure of 69034-09-9

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General Information

  • CAS No. 69034-09-9
  • Cat. No. CS-0101604
  • Purity ≥97%
  • MDL No. MFCD14702304
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrF₃N₂
  • Molecular Weight 226.98
  • Synonym(s) None
  • SMILES FC(C1=CN=C(Br)N=C1)(F)F

Description

2-Bromo-5-(trifluoromethyl)pyrimidine is a halogenated pyrimidine scaffold featuring a strongly electron-withdrawing trifluoromethyl group. This combination enables selective cross-coupling reactions, particularly in palladium-catalyzed transformations. The molecule exhibits enhanced stability and reactivity in C–H functionalization and heterocycle synthesis.

Application

2-Bromo-5-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to install aryl, heteroaryl, and alkyl substituents at the 2-position. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the bromine facilitates efficient functionalization under standard Suzuki, Stille, or Negishi conditions. Bench-stable and readily purified, it functions reliably in the synthesis of kinase inhibitors, antiviral agents, and other bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.2579
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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