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Structure of 450-91-9
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4-Fluoro-2-methoxyaniline features a fluorine atom at the para position and a methoxy group at the ortho position relative to the amine, creating a uniquely activated aromatic scaffold. This electron-rich, bench-stable aniline derivative enables direct coupling reactions and serves as a key intermediate in pharmaceutical synthesis.
4-Fluoro-2-methoxyaniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Its ortho-methoxy and para-fluoro substituents offer orthogonal reactivity for sequential functionalization, while the aniline nitrogen supports facile protection and derivatization. Bench-stable and readily purified by column chromatography, it functions efficiently in standard cross-coupling and electrophilic substitution workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H312+H332-H315-H319-H331-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: