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CS-W001157 4
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1H-Benzimidazole-2-ethanamine, dihydrochloride

  • CAS No. 4499-07-4

  • Cat. No. CS-0030387
  • Molecule weight234.13
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1H-Benzimidazole-2-ethanamine, dihydrochloride|CS-0030387

Structure of 4499-07-4

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General Information

  • CAS No. 4499-07-4
  • Cat. No. CS-0030387
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃Cl₂N₃
  • Molecular Weight 234.13
  • Synonym(s) 2-(1H-Benzo[d]imidazol-2-yl)ethanamine hydrochloride
  • SMILES NCCC1=NC2=CC=CC=C2N1.[H]Cl.[H]Cl

Description

This dihydrochloride salt features a benzimidazole-ethylamine scaffold with enhanced solubility and stability under standard conditions. The protonated amine facilitates efficient coupling in synthetic workflows, while the rigid aromatic core supports targeted interactions in medicinal chemistry applications.

Application

2-(1H-benzo[d]imidazol-2-yl)ethan-1-amine dihydrochloride serves as a versatile building block for bioactive heterocycles, enabling efficient access to fused imidazole scaffolds. The diamine functionality facilitates nucleophilic substitution and coupling reactions, while the dihydrochloride salt form ensures excellent bench stability and solubility in polar solvents. Its compatibility with standard synthetic workflows supports rapid incorporation into pharmaceutical intermediates and functional materials.

Synthesis

  • Route1
    • null|null
      189560-91-6
    • ~95%
    • In-stock
      1H-Benzimidazole-2-ethanamine, dihydrochloride|CS-0030387
      4499-07-4

    References

    • VERTEX PHARMACEUTICALS, INCORPORATED Patent: WO2005/42497 A2, 2005 ; Location in patent: Page/Page column 221 ; WO 2005/042497 A2
  • Route2
    • null|null
      95-54-5
    • In-stock
      β-Alanine|CS-W020126
      107-95-9
    • ~74%
    • In-stock
      1H-Benzimidazole-2-ethanamine, dihydrochloride|CS-0030387
      4499-07-4

    References

    • Nicolaou; Trujillo, John I.; Jandeleit, Bernd; Chibale, Kelly; Rosenfeld; Diefenbach; Cheresh; Goodman Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 8 p. 1185 - 1208

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.9077
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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