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Structure of 44864-47-3
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(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid features a chiral center flanked by a trifluoromethyl group and a hydroxyl-bearing methyl moiety, delivering enhanced steric and electronic properties. This bench-stable compound integrates readily into asymmetric synthesis workflows, where its polar functionality enables selective transformations under mild conditions.
(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid serves as a valuable chiral building block for fluorinated bioactive molecules, enabling direct incorporation of a trifluoromethyl group adjacent to a stereogenic center. Its hydroxyl and carboxylic acid functionalities provide orthogonal handles for derivatization, while the geminal trifluoromethyl motif imparts enhanced metabolic stability and lipophilicity. The compound exhibits bench stability and facilitates efficient purification, making it well-suited for medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H290-H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: