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CS-W001157 4
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4-(4-Nitrophenyl)morpholin-3-one

  • CAS No. 446292-04-2

  • Cat. No. CS-B0475
  • Purity≥98%
  • MDL No.MFCD08236741

*For research and further manufacturing use only, not for direct human use.

4-(4-Nitrophenyl)morpholin-3-one|CS-B0475

Structure of 446292-04-2

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General Information

  • CAS No. 446292-04-2
  • Cat. No. CS-B0475
  • Purity ≥98%
  • MDL No. MFCD08236741
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀N₂O₄
  • Molecular Weight 222.20
  • Synonym(s) 4-(4-Nitrophenyl)morpholin-3-on
  • SMILES O=C1N(CCOC1)C2=CC=C([N+]([O-])=O)C=C2

Description

4-(4-Nitrophenyl)morpholin-3-one is a bench-stable, electron-deficient heterocycle featuring a para-nitroaryl group that enhances reactivity in cross-coupling and conjugate addition processes. This morpholinone scaffold integrates readily into complex molecular architectures, offering high functional group tolerance and predictable regioselectivity under standard conditions.

Synthesis

  • Route1

    References

    • ENANTIA, S.L.; RAFECAS JANE, Llorenc; COMELY, Alexander Christian; FERRALI, Alessandro; AMELA CORTES, Celia; PASTO AGUILA, Mireia Patent: WO2011/80341 A1, 2011 ; Location in patent: Page/Page column 15 ;
  • Route2

    References

    • MERCK PATENT GMBH Patent: WO2006/34789 A1, 2006 ; Location in patent: Page/Page column 41 ;
  • Route3
    • In-stock
      Rivaroxaban impurity 48|CS-D1427
      109-11-5
    • null|null
      586-78-7
    • ~%
    • In-stock
      4-(4-Nitrophenyl)morpholin-3-one|CS-B0475
      446292-04-2

    References

    • GALAPAGOS NV; MENET, Christel Jeanne Marie; BLANC, Javier; JOUANNIGOT, Nolwenn; HODGES, Alastair James; VAN ROMPAEY, Luc Juliaan Corina; FLETCHER, Stephen Robert Patent: WO2010/10189 A1, 2010 ; Location in patent: Page/Page column 55 ; WO 2010/010189 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.68
  • LogP   0.958
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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