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CS-W001157 4
Total: USD 88.00

1-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

  • CAS No. 445303-24-2

  • Cat. No. CS-0202251
  • Molecule weight267.08
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid|CS-0202251

Structure of 445303-24-2

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General Information

  • CAS No. 445303-24-2
  • Cat. No. CS-0202251
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇BrN₂O₂
  • Molecular Weight 267.08
  • Synonym(s) None
  • SMILES O=C(C1=CN(C2=CC=CC(Br)=C2)C=N1)O

Description

This imidazole derivative features a brominated phenyl group at the 3-position and a carboxylic acid at the 4-position, enabling direct coupling in cross-coupling reactions. The electron-deficient imidazole core enhances reactivity in transition-metal catalyzed transformations, while the bench-stable structure facilitates handling under standard conditions.

Application

1-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds. The bromo substituent enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid group facilitates derivatization via amide formation or esterification. Its stability under standard bench conditions and compatibility with diverse reaction environments make it a practical choice for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   2.333
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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