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CS-W001157 4
Total: USD 88.00

1-(4-Chlorophenyl)-1H-imidazole-4-carboxylic acid

  • CAS No. 445302-22-7

  • Cat. No. CS-0198325
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(4-Chlorophenyl)-1H-imidazole-4-carboxylic acid|CS-0198325

Structure of 445302-22-7

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General Information

  • CAS No. 445302-22-7
  • Cat. No. CS-0198325
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇ClN₂O₂
  • Molecular Weight 222.63
  • Synonym(s) None
  • SMILES O=C(C1=CN(C2=CC=C(Cl)C=C2)C=N1)O

Description

This imidazole-carboxylic acid features a 4-chlorophenyl substituent that enhances electron-withdrawing character and improves solubility in organic media. The carboxylic acid group enables direct coupling reactions, while the aromatic imidazole core provides rigidity and metabolic stability. Ideal for medicinal chemistry applications requiring bioisosteric replacement or scaffold decoration.

Application

1-(4-Chlorophenyl)-1H-imidazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its robust bench stability, tolerance to common reaction conditions, and compatibility with amide bond formation facilitate efficient synthesis of target molecules for drug discovery programs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   2.2239
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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