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CS-W001157 4
Total: USD 88.00

Pomalidomide-COCH2Cl

  • CAS No. 444287-84-7

  • Cat. No. CS-0503834
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Pomalidomide-COCH2Cl|CS-0503834

Structure of 444287-84-7

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General Information

  • CAS No. 444287-84-7
  • Cat. No. CS-0503834
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₂ClN₃O₅
  • Molecular Weight 349.73
  • Synonym(s) None
  • SMILES O=C(CCl)NC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O

Description

Pomalidomide-COCH2Cl features a chloromethylcarbonyl handle appended to the pomalidomide scaffold, enabling site-specific conjugation in chemical biology applications. This derivative integrates readily into bioconjugation workflows, offering a stable, moisture-tolerant linkage for targeted protein modification and probe development.

Application

Pomalidomide-COCH₂Cl serves as a versatile synthetic intermediate for the derivatization of the pomalidomide core. The chloroacetyl group enables site-specific functionalization via nucleophilic substitution, facilitating the construction of targeted analogs for medicinal chemistry campaigns. Its bench-stable nature and compatibility with standard amide coupling protocols support efficient downstream processing in API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   112.65
  • LogP   0.0424
  • H_Acceptors   8
  • H_Donors   2
  • Rotatable_Bonds   3

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