Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Fluoropyridine-5-boronic acid pinacol ester

  • CAS No. 444120-95-0

  • Cat. No. CS-W013102
  • Purity≥97%
  • MDL No.MFCD03412792

*For research and further manufacturing use only, not for direct human use.

2-Fluoropyridine-5-boronic acid pinacol ester|CS-W013102

Structure of 444120-95-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 444120-95-0
  • Cat. No. CS-W013102
  • Purity ≥97%
  • MDL No. MFCD03412792
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅BFNO₂
  • Molecular Weight 223.06
  • Synonym(s) 6-Fluoropyridine-3-boronic acid pinacol ester
  • SMILES CC1(C)C(C)(C)OB(C2=CN=C(F)C=C2)O1

Description

This boronate ester features a fluorinated pyridine core, enabling direct incorporation into Suzuki-Miyaura couplings under standard conditions. The pinacol protection enhances stability and solubility in organic solvents, simplifying handling and integration into complex molecular architectures.

Application

2-Fluoropyridine-5-boronic acid pinacol ester serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. Its fluorinated pyridine core enables efficient late-stage functionalization in medicinal chemistry and agrochemical synthesis. The pinacol boronate ester offers enhanced stability, excellent functional group tolerance, and compatibility with standard reaction conditions, facilitating the construction of complex heterocyclic scaffolds.

Synthesis

  • Route1

    References

    • PHARMACIA and UPJOHN COMPANY LLC Patent: WO2006/126081 A2, 2006 ; Location in patent: Page/Page column 52-53 ;
  • Route2

    References

    • Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890
  • Route3

    References

    • Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain Tetrahedron, 2002 , vol. 58, # 14 p. 2885 - 2890

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   31.35
  • LogP   1.5199
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 444120-95-0 sigma444120-95-0 manufacturer444120-95-0 price444120-95-0 structure444120-95-0 SDSbuy 444120-95-0444120-95-0 supplier444120-95-0 uses444120-95-0 molecular weightprice of 444120-95-0444120-95-0 chemical name formula of 444120-95-0
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label