Lot numbers can be found on the outside label of a product:
Morpholin-2-one
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CAS No. 4441-15-0
- Cat. No. CS-0098127
- Purity≥97%
- MDL No.MFCD17010143
*For research and further manufacturing use only, not for direct human use.
Structure of 4441-15-0
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General Information
- CAS No. 4441-15-0
- Cat. No. CS-0098127
- Purity ≥97%
- MDL No. MFCD17010143
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₇NO₂
- Molecular Weight 101.10
- Synonym(s) morpholin-2-one hydrochloride
- SMILES O=C1CNCCO1
Description
Morpholin-2-one is a bench-stable, moisture-tolerant heterocycle featuring a lactam core that integrates readily into synthetic scaffolds. This electron-deficient ring system enables direct functionalization at the C3 position, facilitating efficient coupling reactions in medicinal chemistry workflows.
Application
Morpholin-2-one serves as a versatile scaffold in medicinal chemistry, enabling the construction of diverse heterocyclic systems through nucleophilic displacement and cyclization reactions. Its amide-like functionality exhibits favorable bench stability and moderate solubility, facilitating purification and integration into multi-step syntheses. Functions as a key building block for bioactive molecules, particularly in kinase inhibitors and CNS-targeted therapeutics, owing to its balanced polarity and metabolic stability.
Synthesis
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Route1
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105-39-5 - ~85%
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In-stock
4441-15-0
References
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COLORADO STATE UNIVERSITY RESEARCH FOUNDATION Patent: US2011/224431 A1, 2011 ; Location in patent: Page/Page column 6-7 ;
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Route2
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In-stock
5453-99-6 - ~%
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In-stock
4441-15-0
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503187-88-0
References
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DeLucca, George V. Patent: US2003/144277 A1, 2003 ; US 20030144277 A1
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Route3
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598-21-0
- ~%
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In-stock
4441-15-0
References
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The Procter and Gamble Company Patent: US2003/162778 A1, 2003 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.33
- LogP -0.8672
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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