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CS-W001157 4
Total: USD 88.00

5-Fluoroisatin

  • CAS No. 443-69-6

  • Cat. No. CS-W007549
  • Purity≥97%
  • MDL No.MFCD00022795

*For research and further manufacturing use only, not for direct human use.

5-Fluoroisatin|CS-W007549

Structure of 443-69-6

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General Information

  • CAS No. 443-69-6
  • Cat. No. CS-W007549
  • Purity ≥97%
  • MDL No. MFCD00022795
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄FNO₂
  • Molecular Weight 165.12
  • Synonym(s) None
  • SMILES C1=C(F)C=CC2=C1C(C(=O)N2)=O

Description

5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).5-Fluoroisatin may be used:as reaction-based probe for live-cell detection of peroxynitrite by 19F magnetic resonance spectroscopyin non-invasive detection of peroxynitrite (ONOO(-)) formation in living lung epithelial cells stimulated with interferon- (IFN-)in the synthesis of bis-Schiff bases, via condensation with aromatic primary bis-amines in water suspension medium without using any organic solvent or acid catalystin the synthesis of 3-acetonyl-5-fluoro-3-hydroxyoxindole

Synthesis

  • Route1
    • (E)-N-(4-Fluorophenyl)-2-(hydroxyimino)acetamide|CS-0356649
      879274-72-3
    • ~53%
    • In-stock
      5-Fluoroisatin|CS-W007549
      443-69-6

    References

    • Wilson, Dean; Fanning, Lev T.D.; Krenitsky, Paul; Termin, Andreas; Joshi, Pramod; Sheth, Urvi Patent: US2008/167305 A1, 2008 ; Location in patent: Page/Page column 40 ;
  • Route2
    • In-stock
      2,2,2-Trichloro-1-ethoxyethan-1-ol|CS-0580826
      515-83-3
    • null|null
      371-40-4
    • ~62%
    • In-stock
      5-Fluoroisatin|CS-W007549
      443-69-6

    References

    • Xie, Wenge; Herbert, Brian; Ma, Jianguo; Nguyen, Truc Minh; Schumacher, Richard; Gauss, Carla Maria; Tehim, Ashok Patent: US2005/250808 A1, 2005 ; Location in patent: Page/Page column 39 ; US 20050250808 A1
  • Route3
    • N-(4-Fluorophenyl)-2-(N-hydroxyimino)acetamide|CS-0244884
      351-09-7
    • ~62%
    • In-stock
      5-Fluoroisatin|CS-W007549
      443-69-6

    References

    • Jnaneshwara; Bedekar; Deshpande Synthetic Communications, 1999 , vol. 29, # 20 p. 3627 - 3633

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   0.9605
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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