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CS-W001157 4
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6-Fluoro-1H-indole-2,3-dione

  • CAS No. 324-03-8

  • Cat. No. CS-0020156
  • Purity≥98%
  • MDL No.MFCD03618556

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-1H-indole-2,3-dione|CS-0020156

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General Information

  • CAS No. 324-03-8
  • Cat. No. CS-0020156
  • Purity ≥98%
  • MDL No. MFCD03618556
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄FNO₂
  • Molecular Weight 165.12
  • Synonym(s) 6-Fluoroisatin; 6-Fluoro-1H-indole-2,3-dione
  • SMILES O=C1NC2=C(C=CC(F)=C2)C1=O

Description

6-Fluoro-1H-indole-2,3-dione features a fluorinated indole core with dual carbonyl groups, delivering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into synthetic routes for bioactive molecules, particularly in medicinal chemistry applications requiring halogenated heterocyclic motifs.

Application

6-Fluoro-1H-indole-2,3-dione serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its reactive quinone core facilitates nucleophilic addition and cycloaddition reactions, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   0.9605
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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