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CS-W001157 4
Total: USD 88.00

H-Thr(Bzl)-OH

  • CAS No. 4378-10-3

  • Cat. No. CS-W015160
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

H-Thr(Bzl)-OH|CS-W015160

Structure of 4378-10-3

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General Information

  • CAS No. 4378-10-3
  • Cat. No. CS-W015160
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO₃
  • Molecular Weight 209.25
  • Synonym(s) None
  • SMILES C[C@@H](OCC1=CC=CC=C1)[C@H](N)C(O)=O

Description

H-Thr(Bzl)-OH is a protected threonine derivative featuring a benzyl group at the hydroxyl position, offering enhanced stability and ease of handling. This residue integrates seamlessly into peptide synthesis workflows, enabling efficient access to threonine-containing sequences under standard conditions.

Application

H-Thr(Bzl)-OH serves as a stable, bench-ready building block for the synthesis of peptide-based scaffolds and bioactive molecules. The benzyl-protected hydroxyl group ensures orthogonal handling in multi-step syntheses, while the N-terminal amine enables straightforward coupling reactions. Its well-documented compatibility with standard Fmoc-SPPS protocols facilitates efficient incorporation into complex sequences.

Synthesis

  • Route1

    References

    • Sajiki, Hironao; Hirota, Kosaku Tetrahedron, 1998 , vol. 54, # 46 p. 13981 - 13996
  • Route2
    • null|null
      100-39-0
    • ~%
    • In-stock
      H-Thr(Bzl)-OH|CS-W015160
      4378-10-3

    References

    • Synthetic Communications, , vol. 19, # 20 p. 3589 - 3594
  • Route3
    • In-stock
      Benzyl 2,2,2-trichloroacetimidate|CS-M0017
      81927-55-1
    • null|null
      75444-38-1
    • ~%
    • In-stock
      H-Thr(Bzl)-OH|CS-W015160
      4378-10-3

    References

    • Journal of the Chemical Society - Perkin Transactions 1, , # 5 p. 621 - 624

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   1.0036
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

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