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CS-W001157 4
Total: USD 88.00

5-Bromo-2-trifluoromethylpyridine

  • CAS No. 436799-32-5

  • Cat. No. CS-D0796
  • Purity≥98%
  • MDL No.MFCD06657686

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-trifluoromethylpyridine|CS-D0796

Structure of 436799-32-5

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General Information

  • CAS No. 436799-32-5
  • Cat. No. CS-D0796
  • Purity ≥98%
  • MDL No. MFCD06657686
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₃N
  • Molecular Weight 225.99
  • Synonym(s) None
  • SMILES FC(C1=NC=C(Br)C=C1)(F)F

Description

5-Bromo-2-trifluoromethylpyridine features a trifluoromethyl group at the pyridine ring's 2-position and a bromine substituent at the 5-position, creating a uniquely electron-deficient heteroaromatic scaffold. This combination enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive molecules and advanced materials. The compound exhibits excellent stability under standard conditions and integrates readily into synthetic workflows requiring halogenated pyridines.

Synthesis

  • Route1
    • null|null
      383-62-0
    • In-stock
      5-Bromo-2-iodopyridine|CS-W002668
      223463-13-6
    • ~53%
    • In-stock
      5-Bromo-2-trifluoromethylpyridine|CS-D0796
      436799-32-5

    References

    • Kalypsys, Inc. Patent: US2005/234046 A1, 2005 ; Location in patent: Page/Page column 73 ; US 20050234046 A1
  • Route2

    References

    • Ekambome Bassene, Carine; Suzenet, Franck; Hennuyer, Nathalie; Staels, Bart; Caignard, Daniel-Henri; Dacquet, Catherine; Renard, Pierre; Guillaumet, Gerald Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4528 - 4532
  • Route3

    References

    • Pinard, Emmanuel; Alanine, Alexander; Alberati, Daniela; Bender, Markus; Borroni, Edilio; Bourdeaux, Patrick; Brom, Virginie; Burner, Serge; Fischer, Holger; Hainzl, Dominik; Halm, Remy; Hauser, Nicole; Jolidon, Synese; Lengyel, Judith; Marty, Hans-Peter; Meyer, Thierry; Moreau, Jean-Luc; Mory, Roland; Narquizian, Robert; Nettekoven, Mathias; Norcross, Roger D.; Puellmann, Bernd; Schmid, Philipp; Schmitt, Sebastien; Stalder, Henri; Wermuth, Roger; Wettstein, Joseph G.; Zimmerli, Daniel Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4603 - 4614

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8629
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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