5-Bromo-4-chloro-2-(trifluoromethyl)pyridine

Name: 5-Bromo-4-chloro-2-(trifluoromethyl)pyridine
Brand: ChemScene
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CAS No. 1211537-20-0
Cat. No. CS-0173675
Purity≥96%
MDL No.MFCD18257603

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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5-Bromo-4-chloro-2-(trifluoromethyl)pyridine|CS-0173675

Structure of 1211537-20-0

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General Information

CAS No. 1211537-20-0
Cat. No. CS-0173675
Purity ≥96%
MDL No. MFCD18257603
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrClF₃N
Molecular Weight 260.44
Synonym(s) None
SMILES FC(C1=NC=C(Br)C(Cl)=C1)(F)F

Description

5-Bromo-4-chloro-2-(trifluoromethyl)pyridine is a halogenated pyridine derivative featuring orthogonal reactivity at bromo and chloro sites, enabling selective cross-coupling. The trifluoromethyl group imparts enhanced electron-withdrawal and metabolic stability, making this scaffold valuable in medicinal chemistry and agrochemical synthesis.

Application

5-Bromo-4-chloro-2-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the bromo and chloro substituents allow sequential functionalization under selective catalytic conditions. This compound exhibits excellent bench stability and facilitates the construction of complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 12.89
LogP 3.5163
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Bromo-4-chloro-2-(trifluoromethyl)pyridine

CAS No. 1211537-20-0

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