3-Chloro-5-(trifluoromethoxy)benzaldehyde

Name: 3-Chloro-5-(trifluoromethoxy)benzaldehyde
Brand: ChemScene
Availability: InStock
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CAS No. 433926-48-8
Cat. No. CS-0021646
Purity≥97%
MDL No.MFCD06660305

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Chloro-5-(trifluoromethoxy)benzaldehyde|CS-0021646

Structure of 433926-48-8

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General Information

CAS No. 433926-48-8
Cat. No. CS-0021646
Purity ≥97%
MDL No. MFCD06660305
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄ClF₃O₂
Molecular Weight 224.56
Synonym(s) 3-Chloro-5-trifluoromethoxybenzaldehyde; 3-chloro-5-(trifluoromethoxy)bnezaldehyde
SMILES O=CC1=CC(OC(F)(F)F)=CC(Cl)=C1

Description

3-Chloro-5-(trifluoromethoxy)benzaldehyde features a trifluoromethoxy group that enhances electron-withdrawing character and metabolic stability, while the chloro substituent introduces steric and electronic modulation. This combination enables efficient incorporation into pharmaceutical intermediates and functional materials. The aldehyde functionality offers direct reactivity for nucleophilic addition and condensation reactions under standard conditions.

Application

3-Chloro-5-(trifluoromethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to functionalized heterocycles and biaryl scaffolds. Its electron-withdrawing trifluoromethoxy group enhances electrophilicity at the aldehyde center, facilitating nucleophilic addition and coupling reactions. The molecule exhibits excellent bench stability and compatibility with standard reaction conditions, allowing straightforward purification and integration into multi-step syntheses.

Synthesis

Route1
- 433926-47-7
- ~94%
- In-stock
  
  433926-48-8
References
- ASTRAZENECA AB Patent: WO2003/101956 A1, 2003 ; Location in patent: Page 49 ; WO 03/101956 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 26.3
LogP 3.0511
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3-Chloro-5-(trifluoromethoxy)benzaldehyde

CAS No. 433926-48-8

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