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Structure of 433926-46-6
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3-Chloro-5-(trifluoromethoxy)benzoic acid features a trifluoromethoxy group that enhances lipophilicity and metabolic stability, while the chloro substituent provides a handle for further functionalization. This electron-withdrawing combination imparts strong acidity and improves binding affinity in medicinal chemistry applications. The carboxylic acid moiety enables direct coupling or salt formation, facilitating integration into bioactive molecules under standard conditions.
3-Chloro-5-(trifluoromethoxy)benzoic acid serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling direct incorporation of electron-withdrawing trifluoromethoxy and chloro substituents on an aromatic core. The carboxylic acid functionality facilitates derivatization via esterification, amide coupling, or decarboxylation protocols, while the ortho-chloro and para-trifluoromethoxy groups exhibit good bench stability and compatibility with standard coupling reactions. This compound functions as a key intermediate in the construction of bioactive heterocycles and functionalized aryl scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P280-P304+P340-P405-P501
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Lot numbers can be found on the outside label of a product: