Lot numbers can be found on the outside label of a product:
Boc-L-Tyrosine methyl ester
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CAS No. 4326-36-7
- Cat. No. CS-M3312
- Purity≥98%
- MDL No.MFCD00191181
*For research and further manufacturing use only, not for direct human use.
Structure of 4326-36-7
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General Information
- CAS No. 4326-36-7
- Cat. No. CS-M3312
- Purity ≥98%
- MDL No. MFCD00191181
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₅H₂₁NO₅
- Molecular Weight 295.33
- Synonym(s) None
- SMILES OC1=CC=C(C[C@H](NC(OC(C)(C)C)=O)C(OC)=O)C=C1
Description
Boc-L-Tyrosine methyl ester serves as a protected amino acid building block for peptide synthesis, featuring a stable tert-butoxycarbonyl group and a methyl ester at the C-terminus. The phenolic hydroxyl remains free for selective derivatization, enabling efficient incorporation into complex peptide sequences under standard conditions.
Application
Boc-L-Tyrosine methyl ester serves as a versatile building block in peptide synthesis and medicinal chemistry, enabling efficient incorporation of tyrosine residues with orthogonal protection. The Boc group provides stable N-terminal protection under acidic conditions, while the methyl ester facilitates straightforward deprotection and downstream derivatization. Its robust bench stability and compatibility with standard coupling protocols make it ideal for multi-step synthetic sequences.
Synthesis
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References
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Rehman, Abdul; Soni, Ajay; Naik, Keshav; Nair, Sreeji; Palle, Venkata P.; Dastidar, Sunanda; Ray, Abhijit; Alam; Salman, Mohammad; Cliffe, Ian A.; Sattigeri, Viswajanani Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5514 - 5520
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References
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Chen, Ping; Cheng, Peter T. W.; Alam, Masud; Beyer, Barbara D.; Bisacchi, Gregory S.; Dejneka, Tamara; Evans, Adelaide J.; Greytok, Jill A.; Hermsmeier, Mark A.; Humphreys, W. Griffith; Jacobs, Glenn A.; Kocy, Octavian; Lin, Pin-Fang; Lis, Karen A.; Marella, Michael A.; Ryono, Denis E.; Sheaffer, Amy K.; Spergel, Steven H.; Sun, Chong-Qing; Tino, Joseph A.; Vite, Gregory; Colonno, Richard J.; Zahler, Robert; Barrish, Joel C. Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 1991 - 2007
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Route3
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67-56-1 -
In-stock
24424-99-5 - ~88%
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In-stock
4326-36-7
References
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BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. Patent: US2007/259883 A1, 2007 ; Location in patent: Page/Page column 8 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 84.86
- LogP 2.001
- H_Acceptors 5
- H_Donors 2
- Rotatable_Bonds 4
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Key Words
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