Z-Tyr-OMe

Name: Z-Tyr-OMe
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 13512-31-7
Cat. No. CS-0150966
Purity≥95%
MDL No.MFCD00038784

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

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Description

Z-Tyr-OMe features a benzyl-protected tyrosine methyl ester with enhanced solubility and stability under standard peptide synthesis conditions. The Z group provides reliable protection of the α-amino function, while the methyl ester facilitates efficient coupling and downstream deprotection. This derivative enables streamlined access to tyrosine-containing sequences in synthetic peptides.

Application

Z-Tyr-OMe serves as a key chiral building block in peptide synthesis, offering orthogonal protection of both amine and phenolic hydroxyl functionalities. The benzoyl (Z) group provides robust amine protection compatible with standard coupling conditions, while the methyl ester stabilizes the C-terminal carboxylate. This dual protection enables efficient sequential elongation in solid-phase and solution-phase peptide assembly, with excellent bench stability and straightforward deprotection under mild hydrogenolysis or acidic conditions.

General Information

CAS No. 13512-31-7
Cat. No. CS-0150966
Purity ≥95%
MDL No. MFCD00038784
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₈H₁₉NO₅
Molecular Weight 329.35
Synonym(s) (S)-methyl 2-(benzyloxycarbonylamino)-3-(4-hydroxyphenyl)propanoate
SMILES COC([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=C(O)C=C2)=O

Computational Chemistry Data

TPSA 84.86
LogP 2.4027
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Tyrosine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Z-Tyr-OMe

CAS No. 13512-31-7

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