H-D-Phg(4-Cl)-OH

Name: H-D-Phg(4-Cl)-OH
Brand: ChemScene
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CAS No. 43189-37-3
Cat. No. CS-W022748
Purity≥96%
MDL No.MFCD03839815

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 43189-37-3

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General Information

CAS No. 43189-37-3
Cat. No. CS-W022748
Purity ≥96%
MDL No. MFCD03839815
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈ClNO₂
Molecular Weight 185.61
Synonym(s) None
SMILES O=C(O)[C@H](N)C1=CC=C(Cl)C=C1

Description

H-D-Phg(4-Cl)-OH is a bench-stable, moisture-tolerant dipeptide building block featuring a para-chlorophenylglycine residue. This electron-deficient aromatic moiety integrates seamlessly into peptide sequences, enabling efficient synthesis of bioactive analogs with enhanced metabolic stability and targeted receptor affinity.

Application

H-D-Phg(4-Cl)-OH serves as a valuable building block for peptide synthesis, offering a para-chlorophenylglycine residue with enhanced hydrophobicity and metabolic stability. Its bench-stable, crystalline form facilitates straightforward handling and purification, while the aromatic chlorine substituent enables downstream functionalization via cross-coupling or nucleophilic substitution. This residue functions effectively in both solution-phase and solid-phase peptide synthesis workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 63.32
LogP 1.4244
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Glycine and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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H-D-Phg(4-Cl)-OH

CAS No. 43189-37-3

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