Lot numbers can be found on the outside label of a product:
2-Chloro-6-methylquinoline
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CAS No. 4295-11-8
- Cat. No. CS-0152990
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 4295-11-8
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General Information
- CAS No. 4295-11-8
- Cat. No. CS-0152990
- Purity ≥98%
- MDL No. None
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₈ClN
- Molecular Weight 177.63
- Synonym(s) T66 BNJ CG H1 [WLN]
- SMILES CC1=CC=C2C(=C1)C=CC(=N2)Cl
Description
2-Chloro-6-methylquinoline is a heterocyclic compound featuring a quinoline core with chlorine and methyl substituents at the 2- and 6-positions, respectively. This configuration imparts electron-deficient character at the aromatic ring, enhancing its utility in transition metal-catalyzed cross-coupling reactions. The molecule exhibits excellent bench stability and solubility in common organic solvents, facilitating straightforward handling in synthetic workflows. Its defined regiochemistry enables precise incorporation into complex molecular architectures, particularly in medicinal chemistry and materials science applications where controlled electronic properties are critical.
Application
2-Chloro-6-methylquinoline serves as a versatile building block in medicinal chemistry and catalytic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive C–Cl bond. The methyl group enhances electronic modulation and provides a handle for further functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical scaffold for constructing complex heterocyclic systems relevant to pharmaceutical development.
Synthesis
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Route1
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In-stock
4053-34-3 - ~91%
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In-stock
4295-11-8
References
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US2009/247579 A1, ; Page/Page column 25; 41 ;
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Route2
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4053-42-3 - ~%
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In-stock
4295-11-8
References
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US2009/264426 A1, ; Page/Page column 40-41 ;
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Route3
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123637-77-4
- ~%
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In-stock
4295-11-8
References
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US2004/102450 A1, ; Page/Page column 70 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 3.19662
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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