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CS-W001157 4
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Spiro[1,2-dihydroindene-3,4'-piperidine]

  • CAS No. 428-38-6

  • Cat. No. CS-0038668
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Spiro[1,2-dihydroindene-3,4'-piperidine]|CS-0038668

Structure of 428-38-6

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General Information

  • CAS No. 428-38-6
  • Cat. No. CS-0038668
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₇N
  • Molecular Weight 187.28
  • Synonym(s) 2,3-Dihydrospiro[indene-1,4'-piperidine]
  • SMILES C1=CC2=C(C=C1)C3(CC2)CCNCC3

Description

Spiro[1,2-dihydroindene-3,4'-piperidine] features a rigid spirocyclic scaffold that imparts enhanced conformational stability and spatial isolation of functional groups. This structural motif enables precise stereocontrol in asymmetric synthesis and facilitates integration into bioactive molecules where defined three-dimensional architecture is critical.

Application

Spiro[1,2-dihydroindene-3,4'-piperidine] serves as a rigid, three-dimensional scaffold enabling the construction of bioactive molecules in medicinal chemistry. Its spirocyclic architecture provides conformational constraint and enhanced metabolic stability, while the piperidine nitrogen offers a versatile handle for functionalization. The compound exhibits good bench stability and compatibility with standard coupling and reduction protocols, facilitating efficient access to diverse heterocyclic architectures and API intermediates.

Synthesis

  • Route1

    References

    • NOVARTIS AG; NOVARTIS PHARMA GMBH Patent: WO2007/38459 A2, 2007 ; Location in patent: Page/Page column 72 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.254
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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