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CS-W001157 4
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(5-Fluoro-2-methoxyphenyl)methanol

  • CAS No. 426831-32-5

  • Cat. No. CS-0043936
  • Purity≥98%
  • MDL No.MFCD00671767

*For research and further manufacturing use only, not for direct human use.

(5-Fluoro-2-methoxyphenyl)methanol|CS-0043936

Structure of 426831-32-5

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General Information

  • CAS No. 426831-32-5
  • Cat. No. CS-0043936
  • Purity ≥98%
  • MDL No. MFCD00671767
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉FO₂
  • Molecular Weight 156.15
  • Synonym(s) Benzenemethanol, 5-fluoro-2-methoxy- (9CI)
  • SMILES COC1=C(CO)C=C(F)C=C1

Description

(5-Fluoro-2-methoxyphenyl)methanol features a fluorinated aromatic core with a methoxy group at the ortho position and a primary alcohol at the benzylic site. This combination imparts enhanced metabolic stability and favorable lipophilicity, making it a valuable building block in medicinal chemistry for accessing bioactive compounds through direct functionalization or coupling reactions.

Application

(5-Fluoro-2-methoxyphenyl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated aromatic scaffolds. Its benzyl alcohol functionality facilitates direct derivatization via oxidation, etherification, or esterification, while the ortho-methoxy and meta-fluoro substituents provide enhanced metabolic stability and modulated electronic properties. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • EP1216225 B1, ; Page/Page column 39 ;
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 78, # 12 p. 5955 - 5963
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 78, # 12 p. 5955 - 5963

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.3266
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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