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CS-W001157 4
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(S)-(+)-1,2-Propanediol

  • CAS No. 4254-15-3

  • Cat. No. CS-0011520
  • Molecule weight76.09
  • Purity≥97%
  • MDL No.MFCD00004539

*For research and further manufacturing use only, not for direct human use.

(S)-(+)-1,2-Propanediol|CS-0011520

Structure of 4254-15-3

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General Information

  • CAS No. 4254-15-3
  • Cat. No. CS-0011520
  • Purity ≥97%
  • MDL No. MFCD00004539
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₈O₂
  • Molecular Weight 76.09
  • Synonym(s) None
  • SMILES C[C@H](O)CO

Description

(S)-(+)-1,2-Propanediol can be used as a reactant to synthesize:Optically active chiral (S)-1, 2-propanediol derivatives using mesogenic carboxylic acids via esterification in the presence of dimethylaminopyridine (DMAP) as a catalyst.3,4-Ethylenedioxythiophenes via Mitsunobu reaction.Vicinal diol cyclic sulfates in the presence of sodium periodate and ruthenium chloride as catalysts.

Application

(S)-(+)-1,2-Propanediol serves as a chiral synthon in asymmetric synthesis, offering reliable stereocontrol in nucleophilic additions and epoxide formations. Its bench-stable, low-moisture-sensitive nature facilitates straightforward handling and purification. Widely employed in the construction of heterocyclic scaffolds and bioactive intermediates, it functions effectively in esterification, etherification, and metal-catalyzed coupling reactions with high functional group tolerance.

Synthesis

  • Route1

    References

    • Licandro, Emanuela; Maiorana, Stefano; Manzotti, Raffaella; Papagni, Antonio; Pryce, Mary; et al. Gazzetta Chimica Italiana, 1997 , vol. 127, # 12 p. 815 - 818
  • Route2
    • null|null
      85550-19-2
    • ~78%
    • In-stock
      (S)-(+)-1,2-Propanediol|CS-0011520
      4254-15-3

    References

    • Petursson, Sigthor; Jonsdottir, Sigridur Tetrahedron Asymmetry, 2011 , vol. 22, # 18-19 p. 1809 - 1812
  • Route3

    References

    • Jeulin, Severine; Champion, Nicolas; Dellis, Philippe; Ratovelomanana-Vidal, Virginie; Genet, Jean-Pierre Synthesis, 2005 , # 20 art. no. Z17405SS, p. 3666 - 3671

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.6405
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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