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CS-W001157 4
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5-Bromo-3-methoxypyridin-2-amine

  • CAS No. 42409-58-5

  • Cat. No. CS-W005608
  • Purity≥98%
  • MDL No.MFCD09909849

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-methoxypyridin-2-amine|CS-W005608

Structure of 42409-58-5

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General Information

  • CAS No. 42409-58-5
  • Cat. No. CS-W005608
  • Purity ≥98%
  • MDL No. MFCD09909849
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂O
  • Molecular Weight 203.04
  • Synonym(s) 5-bromo-3-methoxypyridine-2-amine
  • SMILES BrC1=CN=C(C(=C1)OC)N

Description

5-Bromo-3-methoxypyridin-2-amine features a pyridine core bearing bromo and methoxy substituents at electron-deficient positions, enabling selective cross-coupling reactions. The amino group provides a handle for derivatization, while the methoxy moiety enhances solubility and stability. This compound serves as a key building block in medicinal chemistry and agrochemical synthesis.

Application

5-Bromo-3-methoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromine handle. The methoxy group enhances solubility and modulates electronic properties, while the pyridin-2-amine functionality provides a site for further derivatization. This compound exhibits excellent bench stability and facilitates efficient synthesis of heterocyclic scaffolds relevant to drug discovery pipelines.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.4349
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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