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Structure of 42265-67-8
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4-tert-Butyl-2-chloroaniline features a sterically hindered tert-butyl group adjacent to a chlorinated aromatic ring, enhancing its stability and resistance to oxidation. This electron-deficient aniline derivative facilitates selective coupling reactions in synthetic pathways requiring robust, bench-stable intermediates.
4-tert-Butyl-2-chloroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a robust platform for Suzuki-Miyaura and Buchwald-Hartwig couplings. The ortho-chloro group enables selective functionalization, while the tert-butyl substituent provides steric bulk and enhanced metabolic stability. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses requiring high functional group tolerance and predictable reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: