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CS-W001157 4
Total: USD 88.00

2-Methyl-2-(4-nitrophenyl)propanoic acid

  • CAS No. 42206-47-3

  • Cat. No. CS-0051881
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Methyl-2-(4-nitrophenyl)propanoic acid|CS-0051881

Structure of 42206-47-3

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Description

2-Methyl-2-(4-nitrophenyl)propanoic acid features a sterically hindered tertiary carbon bearing a para-nitroaryl group, delivering enhanced stability and controlled reactivity. This electron-deficient aryl moiety facilitates efficient coupling in synthetic transformations. The compound exhibits robust bench stability and compatibility with standard organic reaction conditions.

Application

2-Methyl-2-(4-nitrophenyl)propanoic acid serves as a versatile building block for heterocyclic synthesis and functionalized aromatic systems. Its benzylic carboxylic acid functionality enables direct derivatization via esterification, amide coupling, or decarboxylation protocols. The electron-withdrawing nitro group enhances the acidity of the α-proton and facilitates subsequent substitution reactions. The molecule exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for scalable synthesis in medicinal chemistry and process development workflows.

General Information

  • CAS No. 42206-47-3
  • Cat. No. CS-0051881
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₄
  • Molecular Weight 209.20
  • Synonym(s) 2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID
  • SMILES CC(C)(C(O)=O)C1=CC=C(C=C1)[N+]([O-])=O

Computational Chemistry Data

  • TPSA   80.44
  • LogP   1.957
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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