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Structure of 42206-47-3
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2-Methyl-2-(4-nitrophenyl)propanoic acid features a sterically hindered tertiary carbon bearing a para-nitroaryl group, delivering enhanced stability and controlled reactivity. This electron-deficient aryl moiety facilitates efficient coupling in synthetic transformations. The compound exhibits robust bench stability and compatibility with standard organic reaction conditions.
2-Methyl-2-(4-nitrophenyl)propanoic acid serves as a versatile building block for heterocyclic synthesis and functionalized aromatic systems. Its benzylic carboxylic acid functionality enables direct derivatization via esterification, amide coupling, or decarboxylation protocols. The electron-withdrawing nitro group enhances the acidity of the α-proton and facilitates subsequent substitution reactions. The molecule exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for scalable synthesis in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: