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CS-W001157 4
Total: USD 88.00

α-[2-(Methylamino)ethyl]benzenemethanol

  • CAS No. 42142-52-9

  • Cat. No. CS-0010500
  • Molecule weight165.24
  • Purity≥98%
  • MDL No.MFCD00674078

*For research and further manufacturing use only, not for direct human use.

α-[2-(Methylamino)ethyl]benzenemethanol|CS-0010500

Structure of 42142-52-9

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General Information

  • CAS No. 42142-52-9
  • Cat. No. CS-0010500
  • Purity ≥98%
  • MDL No. MFCD00674078
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO
  • Molecular Weight 165.24
  • Synonym(s) N-Methyl-3-phenyl-3-hydroxypropylamine
  • SMILES OC(CCNC)C1=CC=CC=C1

Description

Dimyristoyl glycerol (DMG) molecule associates with membrane similar to phospholipids.DMG-PEG 2000 is suitable for use in the preparation of lipid nanoparticle for microRNA and short interfering RNA delivery.

Application

α-[2-(Methylamino)ethyl]benzenemethanol serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard amine functionalization and coupling reactions. Its benzylic alcohol functionality facilitates oxidation to aldehydes or carboxylic acids, while the pendant primary amine supports derivatization via acylation, alkylation, or reductive amination. The molecule exhibits good bench stability and compatibility with common purification methods, making it well-suited for multi-step synthesis and process development workflows.

Synthesis

  • Route1
    • null|null
      877-50-9
    • ~74%
    • In-stock
      α-[2-(Methylamino)ethyl]benzenemethanol|CS-0010500
      42142-52-9

    References

    • Board of Regents, The University of Texas System Patent: US2004/102651 A1, 2004 ; Location in patent: Page 4 ;
  • Route2
    • 3-(Benzyl(methyl)amino)-1-phenylpropanone hydrochloride|CS-0698423
      5409-62-1
    • ~%
    • In-stock
      α-[2-(Methylamino)ethyl]benzenemethanol|CS-0010500
      42142-52-9

    References

    • DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC. Patent: WO2006/37055 A1, 2006 ; Location in patent: Page/Page column 21-22 ;
  • Route3

    References

    • Kellogg, Richard M.; Nieuwenhuijzen, Jose W.; Pouwer; Vries, Ton R.; Broxterman, Quirinus B.; Grimbergen, Reinier F.P.; Kaptein, Bernard; La Crois, Rene M.; De Wever, Ellen; Zwaagstra, Karen; Van Der Laan, Alexander C. Synthesis, 2003 , # 10 p. 1626 - 1638

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   1.3295
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   4

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