EcDsbB-IN-9

Name: EcDsbB-IN-9
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 41933-33-9
Cat. No. CS-0065445
Purity≥97%
MDL No.MFCD00067773

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 41933-33-9

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General Information

CAS No. 41933-33-9
Cat. No. CS-0065445
Purity ≥97%
MDL No. MFCD00067773
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₈Cl₂N₂O
Molecular Weight 255.10
Synonym(s) None
SMILES O=C1C(Cl)=C(C=NN1CC2=CC=CC=C2)Cl

Description

EcDsbB-IN-9 is a potent, selective inhibitor targeting the bacterial disulfide bond formation enzyme DsbB from Escherichia coli. This compound disrupts oxidative protein folding in the periplasm, impairing virulence factor secretion and membrane integrity. Designed for mechanistic studies in redox biology and antimicrobial development, it offers high specificity and stability under physiological conditions.

Application

EcDsbB-IN-9 serves as a selective inhibitor of the bacterial disulfide bond formation enzyme DsbB, enabling targeted disruption of redox homeostasis in *E. coli*. Its stable thioether scaffold offers enhanced metabolic resilience and facilitates straightforward purification, making it well-suited for mechanistic studies and antimicrobial target validation in redox-dependent pathways.

Synthesis

Route1
- In-stock
  
  932-22-9
- 100-39-0
- ~95%
- In-stock
  
  41933-33-9
References
- Ewing, William R.; Zhu, Yeheng; Ellsworth, Bruce A. Patent: US2006/287323 A1, 2006 ; Location in patent: Page/Page column 12 ; US 20060287323 A1
Route2
- In-stock
  
  932-22-9
- 100-44-7
- ~92%
- In-stock
  
  41933-33-9
References
- Cho, Su-Dong; Kweon, Deok-Heon; Kang, Young-Jin; Chung, Hyun-A.; Yoon, Yong-Jin Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 3 p. 601 - 605

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 34.89
LogP 2.5984
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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EcDsbB-IN-9

CAS No. 41933-33-9

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