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CS-W001157 4
Total: USD 88.00

5,6,7,8-Tetrahydronaphthalene-1-carbaldehyde

  • CAS No. 41828-13-1

  • Cat. No. CS-W018374
  • Purity≥98%
  • MDL No.MFCD15474839

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydronaphthalene-1-carbaldehyde|CS-W018374

Structure of 41828-13-1

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General Information

  • CAS No. 41828-13-1
  • Cat. No. CS-W018374
  • Purity ≥98%
  • MDL No. MFCD15474839
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O
  • Molecular Weight 160.21
  • Synonym(s) tetralin-1-carbaldehyde
  • SMILES O=CC1=C2CCCCC2=CC=C1

Description

This bench-stable aldehyde features a fused bicyclic framework that enhances its reactivity in nucleophilic additions. The carbonyl group at the 1-position enables direct incorporation into complex scaffolds, while the saturated ring system imparts favorable solubility and handling properties for synthetic applications.

Application

5,6,7,8-Tetrahydronaphthalene-1-carbaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of biologically relevant scaffolds. Its aldehyde functionality facilitates standard transformations including reductive amination, Grignard additions, and Wittig reactions. The rigid tetralin core provides excellent structural definition for medicinal chemistry applications, while the bench-stable aldehyde group offers predictable reactivity with high functional group tolerance.

Synthesis

  • Route1

    References

    • Connolly, Terrence J.; Durst, Tony Tetrahedron, 1997 , vol. 53, # 47 p. 15969 - 15982
  • Route2
    • In-stock
      Tetralin|CS-W020640
      119-64-2
    • null|null
      25891-31-0
    • ~16%
    • In-stock
      5,6,7,8-Tetrahydronaphthalene-1-carbaldehyde|CS-W018374
      41828-13-1

    References

    • Kantlehner, Willi; Vettel, Markus; Gissel, Alexander; Haug, Erwin; Ziegler, Georg; Ciesielski, Michael; Scherr, Oliver; Haas, Richard Advanced Synthesis and Catalysis, 2000 , vol. 342, # 3 p. 297 - 310
  • Route3
    • null|null
      68-12-2
    • 1-Fluoro-2-(4-iodobutyl)benzene|CS-0516751
      249922-30-3
    • ~36%
    • In-stock
      5,6,7,8-Tetrahydronaphthalene-1-carbaldehyde|CS-W018374
      41828-13-1

    References

    • Bailey, William F.; Longstaff, Sarah C. Tetrahedron Letters, 1999 , vol. 40, # 38 p. 6899 - 6901

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.3779
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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