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CS-W001157 4
Total: USD 88.00

(5,6,7,8-Tetrahydronaphthalen-1-yl)methanol

  • CAS No. 41790-30-1

  • Cat. No. CS-W003875
  • Purity≥95%
  • MDL No.MFCD16037293

*For research and further manufacturing use only, not for direct human use.

(5,6,7,8-Tetrahydronaphthalen-1-yl)methanol|CS-W003875

Structure of 41790-30-1

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General Information

  • CAS No. 41790-30-1
  • Cat. No. CS-W003875
  • Purity ≥95%
  • MDL No. MFCD16037293
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄O
  • Molecular Weight 162.23
  • Synonym(s) 5,6,7,8-Tetrahydro-1-naphthalenemethanol
  • SMILES OCC1=CC=CC2=C1CCCC2

Description

This bench-stable, moisture-tolerant alcohol features a fused bicyclic aromatic core that enhances rigidity and lipophilicity. The primary hydroxymethyl group enables straightforward derivatization, while the tetrahydronaphthalene scaffold imparts favorable solubility in organic media. Ideal for synthetic intermediates in medicinal chemistry and materials science applications.

Application

(5,6,7,8-Tetrahydronaphthalen-1-yl)methanol serves as a versatile synthetic building block in medicinal chemistry and process development. Its benzylic alcohol functionality enables straightforward derivatization via oxidation, protection, or coupling reactions. The tetralin core provides rigidity and lipophilic character beneficial for modulating compound pharmacokinetics. Bench-stable and readily purified by column chromatography, it facilitates efficient integration into multi-step syntheses of bioactive molecules and API intermediates.

Synthesis

  • Route1

    References

    • Warner-Lambert Company Patent: US5610177 A1, 1997 ; US 5610177 A
  • Route2

    References

    • Horn Jensen, Eva; Nielsen, Per Halfdan Heterocycles, 1995 , vol. 41, # 11 p. 2441 - 2458
  • Route3
    • 8-Hydroxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid|CS-0826438
      74145-11-2
    • ~%
    • In-stock
      (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol|CS-W003875
      41790-30-1

    References

    • Connolly, Terrence J.; Durst, Tony Tetrahedron, 1997 , vol. 53, # 47 p. 15969 - 15982

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.0577
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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