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CS-W001157 4
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5-Chlorothiazol-2-amine

  • CAS No. 41663-73-4

  • Cat. No. CS-0019182
  • Purity≥98%
  • MDL No.MFCD01681563

*For research and further manufacturing use only, not for direct human use.

5-Chlorothiazol-2-amine|CS-0019182

Structure of 41663-73-4

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General Information

  • CAS No. 41663-73-4
  • Cat. No. CS-0019182
  • Purity ≥98%
  • MDL No. MFCD01681563
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₃ClN₂S
  • Molecular Weight 134.59
  • Synonym(s) 5-Chloro-1,3-thiazol-2-amine
  • SMILES NC1=NC=C(Cl)S1

Description

5-Chlorothiazol-2-amine delivers a reactive thiazole scaffold with enhanced electrophilicity at the 5-position, enabling direct functionalization in synthetic transformations. This bench-stable heterocycle integrates readily into pharmaceutical intermediates and bioactive molecules through nucleophilic substitution or coupling reactions.

Application

5-Chlorothiazol-2-amine serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its thiazole core provides structural rigidity and enhanced metabolic stability, while the chloro and amino groups enable diverse functionalization via nucleophilic substitution, coupling reactions, and derivatization. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for modular synthesis of bioactive scaffolds and advanced intermediates in API development.

Synthesis

  • Route1

    References

    • Dahlbom; Ekstrand Svensk Kemisk Tidskrift, 1945 , vol. 57, p. 229,232 Full Text Show Details English et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 453,457
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    • In-stock
      5-Chlorothiazol-2-amine|CS-0019182
      41663-73-4

    References

    • English et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 453,457
  • Route3

    References

    • Pedley Journal of the Chemical Society, 1947 , p. 431 Full Text Show Details Paik Ann. Rep. Res. Inst. Tuberc. Kanazawa Univ.Chem.Abstr., 1953 , vol. 11, # 2 p. 39,41 Ann. Rep. Res. Inst. Tuberc. Kanazawa Univ.Chem.Abstr., 1955 , p. 8251

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.3787
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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