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trans-4-Morpholinocyclohexanamine dihydrochloride

  • CAS No. 412356-24-2

  • Cat. No. CS-0060760
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

trans-4-Morpholinocyclohexanamine dihydrochloride|CS-0060760

Structure of 412356-24-2

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General Information

  • CAS No. 412356-24-2
  • Cat. No. CS-0060760
  • Purity ≥97%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₂Cl₂N₂O
  • Molecular Weight 257.20
  • Synonym(s) trans-CyclohexanaMine, 4-(4-Morpholinyl)
  • SMILES N[C@@H]1CC[C@@H](N2CCOCC2)CC1.Cl.Cl

Description

trans-4-Morpholinocyclohexanamine dihydrochloride is a bench-stable, moisture-tolerant amine salt featuring a rigid cyclohexane scaffold with a morpholine ring at the equatorial position. This configuration enhances solubility and reactivity in synthetic transformations. The dihydrochloride form facilitates purification and handling in pharmaceutical process development.

Application

trans-4-Morpholinocyclohexanamine dihydrochloride serves as a versatile bifunctional scaffold in medicinal chemistry, enabling efficient access to bioactive amines through standard amine coupling and reductive amination protocols. The morpholine ring provides enhanced solubility and metabolic stability, while the trans-cyclohexane conformation offers predictable stereochemical control. Its bench-stable crystalline form facilitates handling, purification, and integration into multi-step syntheses of pharmaceutical intermediates and functionalized heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.49
  • LogP   1.4321
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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