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CS-W001157 4
Total: USD 88.00

3-Methylpyrazine-2-carboxylic acid

  • CAS No. 41110-28-5

  • Cat. No. CS-D1600
  • Purity≥98%
  • MDL No.MFCD08705765

*For research and further manufacturing use only, not for direct human use.

3-Methylpyrazine-2-carboxylic acid|CS-D1600

Structure of 41110-28-5

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General Information

  • CAS No. 41110-28-5
  • Cat. No. CS-D1600
  • Purity ≥98%
  • MDL No. MFCD08705765
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₂
  • Molecular Weight 138.12
  • Synonym(s) 3-Methyl-2-pyrazinecarboxylic acid; 2-Methylpyrazine-3-carboxylic acid; 3-Methylpiperazine-2-carboxylic acid; 3-Methylpyrazinoic acid
  • SMILES O=C(C1=NC=CN=C1C)O

Description

3-Methylpyrazine-2-carboxylic acid features a pyrazine core functionalized with a methyl group at the 3-position and a carboxylic acid at the 2-position, delivering enhanced solubility and reactivity. This combination enables efficient coupling in synthetic routes to bioactive heterocycles, particularly in medicinal chemistry scaffolds requiring electron-deficient aromatic systems. The molecule exhibits bench-stable handling characteristics under standard conditions.

Application

3-Methylpyrazine-2-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical research, offering a rigid, electron-deficient pyrazine core with orthogonal functional handles. Its carboxylic acid group enables direct amidation, esterification, or coupling reactions under standard conditions, while the methyl substituent provides a site for selective functionalization. The compound exhibits good bench stability and facilitates efficient synthesis of complex scaffolds via established coupling protocols.

Synthesis

  • Route1
    • 2,3-Dimethylpyrazine, ≥95%|CS-1268382
      5910-89-4
    • ~27%
    • In-stock
      3-Methylpyrazine-2-carboxylic acid|CS-D1600
      41110-28-5

    References

    • Vishweshwar, Peddy; Nangia, Ashwini; Lynch, Vincent M. Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 556 - 565

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.48322
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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