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CS-W001157 4
Total: USD 88.00

6-Oxa-2-azaspiro[3.4]octane

  • CAS No. 410070-90-5

  • Cat. No. CS-0171618
  • Purity≥95%
  • MDL No.MFCD14581249

*For research and further manufacturing use only, not for direct human use.

6-Oxa-2-azaspiro[3.4]octane|CS-0171618

Structure of 410070-90-5

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General Information

  • CAS No. 410070-90-5
  • Cat. No. CS-0171618
  • Purity ≥95%
  • MDL No. MFCD14581249
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO
  • Molecular Weight 113.16
  • Synonym(s) None
  • SMILES C1COCC12CNC2

Description

6-Oxa-2-azaspiro[3.4]octane features a rigid, fused spirocyclic architecture combining an oxygen atom and a nitrogen heteroatom within a strained bicyclic framework. This configuration imparts enhanced metabolic stability and controlled polarity, making it valuable for probing bioactive conformational space in medicinal chemistry campaigns.

Application

6-Oxa-2-azaspiro[3.4]octane serves as a rigid, bicyclic scaffold enabling precise spatial positioning of functional groups in medicinal chemistry. Its stability under standard reaction conditions and compatibility with diverse transformations make it a valuable building block for targeted heterocyclic synthesis. The spirocyclic core facilitates controlled stereochemistry and enhances metabolic resistance in lead optimization.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED; JOHANSSON, Lars, Anders, Mikael Patent: WO2013/11285 A1, 2013 ; Location in patent: Page/Page column 57 ; WO 2013/011285 A1
  • Route2
    • 2-Benzyl-6-oxa-2-azaspiro[3.4]octan-1-one|CS-1248617
      1419590-27-4
    • ~%
    • In-stock
      6-Oxa-2-azaspiro[3.4]octane|CS-0171618
      410070-90-5

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED; JOHANSSON, Lars, Anders, Mikael Patent: WO2013/11285 A1, 2013 ; WO 2013/011285 A1
  • Route3

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED; JOHANSSON, Lars, Anders, Mikael Patent: WO2013/11285 A1, 2013 ; WO 2013/011285 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H225
Precautionary Statements : P210-P243-P273-P403

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   -0.0037
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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