(R)-3-Aminopiperidin-2-one hydrochloride

Name: (R)-3-Aminopiperidin-2-one hydrochloride
Brand: ChemScene
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CAS No. 406216-02-2
Cat. No. CS-0102181
Purity≥97%
MDL No.MFCD09752974

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(R)-3-Aminopiperidin-2-one hydrochloride|CS-0102181

Structure of 406216-02-2

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General Information

CAS No. 406216-02-2
Cat. No. CS-0102181
Purity ≥97%
MDL No. MFCD09752974
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁ClN₂O
Molecular Weight 150.61
Synonym(s) 3-(R)-Amino-piperidin-2-one, HCl
SMILES O=C1NCCC[C@H]1N.Cl

Description

(R)-3-Aminopiperidin-2-one hydrochloride is a bench-stable, moisture-tolerant chiral building block featuring a rigid piperidinone core with a stereodefined amine at the 3-position. This configuration enables selective incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS therapeutics and kinase inhibitors. The hydrochloride salt enhances solubility and handling for solution-phase synthesis.

Application

(R)-3-Aminopiperidin-2-one hydrochloride serves as a key chiral building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its amine and carbonyl functionalities support diverse transformations, including amidation, alkylation, and reductive amination. The hydrochloride salt enhances stability and solubility, facilitating handling and purification in standard synthetic workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 55.12
LogP -0.3545
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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(R)-3-Aminopiperidin-2-one hydrochloride

CAS No. 406216-02-2

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