2-Chloro-5-fluoro-3-nitropyridin-4-amine

Name: 2-Chloro-5-fluoro-3-nitropyridin-4-amine
Brand: ChemScene
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CAS No. 405230-90-2
Cat. No. CS-B0661
Molecule weight191.55
Purity≥97%
MDL No.MFCD19441221

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-fluoro-3-nitropyridin-4-amine|CS-B0661

Structure of 405230-90-2

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General Information

CAS No. 405230-90-2
Cat. No. CS-B0661
Purity ≥97%
MDL No. MFCD19441221
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃ClFN₃O₂
Molecular Weight 191.55
Synonym(s) 4-Pyridinamine, 2-chloro-5-fluoro-3-nitro-
SMILES NC1=C([N+]([O-])=O)C(Cl)=NC=C1F

Description

2-Chloro-5-fluoro-3-nitropyridin-4-amine features a pyridine core functionalized with chlorine, fluorine, nitro, and amino groups at strategic positions. This electron-deficient heterocycle serves as a high-impact scaffold for constructing advanced pharmaceutical intermediates, leveraging its reactivity in cross-coupling and nucleophilic substitution processes under standard conditions.

Application

2-Chloro-5-fluoro-3-nitropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of nitrogen-containing heterocycles via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its orthogonal reactivity—combining a chloro group for Suzuki-Miyaura coupling, a fluoro group for site-selective displacement, and a nitro group amenable to reduction—facilitates efficient diversification. Bench-stable and readily purified by recrystallization, it functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive scaffolds.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 82.05
LogP 1.3645
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-fluoro-3-nitropyridin-4-amine

CAS No. 405230-90-2

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