2,2,2-Trifluoro-N-phenylacetamide

Name: 2,2,2-Trifluoro-N-phenylacetamide
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 404-24-0
Cat. No. CS-W015963
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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*For research and further manufacturing use only, not for direct human use.

2,2,2-Trifluoro-N-phenylacetamide|CS-W015963

Structure of 404-24-0

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Description

2,2,2-Trifluoro-N-phenylacetamide features a trifluoromethyl group flanking a carbonyl-linked phenylamine moiety, delivering enhanced stability and lipophilicity. This structural combination facilitates efficient integration into bioactive scaffolds, particularly in medicinal chemistry applications requiring metabolic resistance and membrane permeability.

Application

2,2,2-Trifluoro-N-phenylacetamide serves as a stable, bench-ready building block for trifluoromethylated aromatic amides. It enables direct incorporation of the trifluoromethyl group into complex scaffolds via standard amide coupling protocols or nucleophilic substitution reactions. The molecule exhibits excellent functional group tolerance and facilitates purification due to its crystalline nature, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

General Information

CAS No. 404-24-0
Cat. No. CS-W015963
Purity ≥95%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆F₃NO
Molecular Weight 189.13
Synonym(s) 2,2,2-Trifluoroacetanilide
SMILES O=C(C(F)(F)F)NC1=CC=CC=C1

Computational Chemistry Data

TPSA 29.1
LogP 2.1874
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2,2,2-Trifluoro-N-phenylacetamide

CAS No. 404-24-0

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