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CS-W001157 4
Total: USD 88.00

1H-Pyrazole-1-carboximidamide hydrochloride

  • CAS No. 4023-02-3

  • Cat. No. CS-W017748
  • Purity≥97%
  • MDL No.MFCD00210087

*For research and further manufacturing use only, not for direct human use.

1H-Pyrazole-1-carboximidamide hydrochloride|CS-W017748

Structure of 4023-02-3

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General Information

  • CAS No. 4023-02-3
  • Cat. No. CS-W017748
  • Purity ≥97%
  • MDL No. MFCD00210087
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇ClN₄
  • Molecular Weight 146.58
  • Synonym(s) None
  • SMILES N=C(N1C=CC=N1)N.Cl

Description

1H-Pyrazole-1-carboximidamide (hydrochloride) features a pyrazole core with a carboximidamide group, delivering a potent hydrogen-bonding scaffold. This bench-stable salt exhibits enhanced solubility and stability under standard conditions, enabling efficient integration into medicinal chemistry campaigns targeting kinase inhibition and receptor modulation.

Application

1H-Pyrazole-1-carboximidamide (hydrochloride) serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrazole-based scaffolds prevalent in medicinal chemistry. Its imidamide functionality facilitates direct derivatization and acts as a key intermediate in the construction of bioactive molecules. The hydrochloride salt enhances bench stability and solubility, simplifying handling and purification in standard synthetic workflows.

Synthesis

  • Route1

    References

    • Bernatowicz, Michael S.; Wu, Youling; Matsueda, Gary R. Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2497 - 2502
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      1H-Pyrazole-1-carboximidamide hydrochloride|CS-W017748
      4023-02-3

    References

    • Kleinmaier, Roland; Keller, Max; Igel, Patrick; Buschauer, Armin; Gschwind, Ruth M. Journal of the American Chemical Society, 2010 , vol. 132, # 32 p. 11223 - 11233
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      1H-Pyrazole-1-carboximidamide hydrochloride|CS-W017748
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    References

    • Zahariev, Sotir; Guarnaccia, Corrado; Lamba, Doriano; Cemazar, Masa; Pongor, Sandor Tetrahedron Letters, 2004 , vol. 45, # 51 p. 9423 - 9426

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS08
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H317-H318-H335-H373-H412
Precautionary Statements : P260-P261-P264-P270-P271-P272-P273-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   67.69
  • LogP   0.04647
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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