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CS-W001157 4
Total: USD 88.00

5-Bromo-1H-benzo[d]imidazole-2-carboxylic acid

  • CAS No. 40197-20-4

  • Cat. No. CS-D0219
  • Purity≥98%
  • MDL No.MFCD06738769
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1H-benzo[d]imidazole-2-carboxylic acid|CS-D0219

Structure of 40197-20-4

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Description

This brominated benzimidazole carboxylic acid features a strategically positioned bromine atom and a carboxylic acid group, enabling direct functionalization in cross-coupling reactions. The electron-deficient heterocycle integrates readily into bioactive scaffolds, offering enhanced solubility and stability under standard conditions for medicinal chemistry applications.

Application

5-Bromo-1H-benzo[d]imidazole-2-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling direct incorporation into pharmaceutical scaffolds via palladium-catalyzed cross-coupling reactions. The carboxylic acid group facilitates derivatization through amide bond formation, while the bromine substituent provides a reliable handle for further functionalization. Its bench-stable crystalline form ensures ease of handling and purification, making it well-suited for iterative medicinal chemistry campaigns and process development in API discovery.

General Information

  • CAS No. 40197-20-4
  • Cat. No. CS-D0219
  • Purity ≥98%
  • MDL No. MFCD06738769
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂O₂
  • Molecular Weight 241.04
  • Synonym(s) 5-Bromo-1H-benzoimidazole-2-carboxylic acid
  • SMILES O=C(C1=NC2=CC(Br)=CC=C2N1)O

Computational Chemistry Data

  • TPSA   65.98
  • LogP   2.0236
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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