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CS-W001157 4
Total: USD 88.00

Fmoc-β-HoArg(Pbf)-OH

  • CAS No. 401915-53-5

  • Cat. No. CS-W009582
  • Purity≥95%
  • MDL No.MFCD03490520

*For research and further manufacturing use only, not for direct human use.

Fmoc-β-HoArg(Pbf)-OH|CS-W009582

Structure of 401915-53-5

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General Information

  • CAS No. 401915-53-5
  • Cat. No. CS-W009582
  • Purity ≥95%
  • MDL No. MFCD03490520
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₅H₄₂N₄O₇S
  • Molecular Weight 662.80
  • Synonym(s) None
  • SMILES O=C(C[C@H](CCCNC(NS(=O)(C1=C(C(C)=C2OC(C)(CC2=C1C)C)C)=O)=N)NC(OCC3C4=C(C=CC=C4)C5=C3C=CC=C5)=O)O

Description

Fmoc-β-HoArg(Pbf)-OH is a protected arginine derivative featuring a β-homoarginine scaffold with a Pbf (pentabenzylphenyl) group for selective deprotection. This stable, bench-ready building block integrates seamlessly into solid-phase peptide synthesis, enabling efficient incorporation of guanidino-containing residues with orthogonal handling and high compatibility across diverse coupling protocols.

Application

Fmoc-β-HoArg(Pbf)-OH serves as a key building block in peptide synthesis, enabling the incorporation of β-homoarginine residues with high fidelity. The Fmoc group provides orthogonal protection for the α-amino function, while the Pbf (para-benzoylphenyl) group ensures stable protection of the guanidine side chain. This derivative exhibits excellent bench stability, facilitates efficient coupling reactions, and supports straightforward deprotection under standard conditions, making it ideal for synthesizing peptidomimetics and bioactive oligomers.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   166.91
  • LogP   5.29023
  • H_Acceptors   7
  • H_Donors   5
  • Rotatable_Bonds   11

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