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CS-W001157 4
Total: USD 88.00

2-Fluoropyridine-4-boronic acid

  • CAS No. 401815-98-3

  • Cat. No. CS-D1044
  • Purity≥98%
  • MDL No.MFCD04112534

*For research and further manufacturing use only, not for direct human use.

2-Fluoropyridine-4-boronic acid|CS-D1044

Structure of 401815-98-3

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General Information

  • CAS No. 401815-98-3
  • Cat. No. CS-D1044
  • Purity ≥98%
  • MDL No. MFCD04112534
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BFNO₂
  • Molecular Weight 140.91
  • Synonym(s) None
  • SMILES FC1=NC=CC(B(O)O)=C1

Application

2-Fluoropyridine-4-boronic acid serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki-Miyaura reactions to construct biaryl and heteroaryl architectures. Its fluorinated pyridine core provides enhanced metabolic stability and targeted electronic modulation, while the boronic acid functionality offers reliable coupling efficiency, bench stability, and compatibility with diverse functional groups in medicinal chemistry and materials synthesis workflows.

Synthesis

  • Route1
    • null|null
      5419-55-6
    • In-stock
      4-Bromo-2-fluoropyridine|CS-D0936
      128071-98-7
    • ~33%
    • In-stock
      2-Fluoropyridine-4-boronic acid|CS-D1044
      401815-98-3

    References

    • Frontier Scientific, Inc. Patent: US7087755 B1, 2006 ; Location in patent: Page/Page column 6 ;
  • Route2
    • null|null
      5419-55-6
    • In-stock
      2-Fluoro-4-iodopyridine|CS-B0944
      22282-70-8
    • ~%
    • In-stock
      2-Fluoropyridine-4-boronic acid|CS-D1044
      401815-98-3

    References

    • Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard Patent: US2004/122237 A1, 2004 ; Location in patent: Page 232-233; 387 ; US 20040122237 A1
  • Route3

    References

    • Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain Tetrahedron, 2002 , vol. 58, # 22 p. 4369 - 4373

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -1.0995
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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