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CS-W001157 4
Total: USD 88.00

(5-Chloro-2-fluoropyridin-4-yl)boronic acid

  • CAS No. 1034659-38-5

  • Cat. No. CS-W018744
  • Purity≥98%
  • MDL No.MFCD05662405

*For research and further manufacturing use only, not for direct human use.

(5-Chloro-2-fluoropyridin-4-yl)boronic acid|CS-W018744

Structure of 1034659-38-5

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General Information

  • CAS No. 1034659-38-5
  • Cat. No. CS-W018744
  • Purity ≥98%
  • MDL No. MFCD05662405
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BClFNO₂
  • Molecular Weight 175.35
  • Synonym(s) B-(5-Chloro-2-fluoro-4-pyridinyl)boronicacid
  • SMILES ClC1=CN=C(C=C1B(O)O)F

Description

This boronate moiety features a strategically positioned chloro and fluoro substituent on the pyridine ring, enabling selective cross-coupling reactions. The electron-deficient heterocycle enhances reactivity in palladium-catalyzed transformations while maintaining bench-stable handling properties under standard conditions.

Application

(5-Chloro-2-fluoropyridin-4-yl)boronic acid serves as a versatile building block in cross-coupling reactions, enabling efficient access to functionalized pyridine scaffolds. Its compatibility with Suzuki-Miyaura coupling under mild conditions facilitates the construction of biologically relevant heterocycles. The molecule exhibits good bench stability and moderate functional group tolerance, simplifying purification and integration into multi-step synthetic sequences.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.4461
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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