Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

  • CAS No. 4018-91-1

  • Cat. No. CS-0199121
  • Purity≥97%
  • MDL No.MFCD09026453

*For research and further manufacturing use only, not for direct human use.

5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine|CS-0199121

Structure of 4018-91-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 4018-91-1
  • Cat. No. CS-0199121
  • Purity ≥97%
  • MDL No. MFCD09026453
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO
  • Molecular Weight 177.25
  • Synonym(s) SKF 87967
  • SMILES COC1=CC=CC2=C1CCC(C2)N

Description

5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine features a methoxy-substituted tetralin core with a primary amine at the 2-position, delivering enhanced solubility and stability. This electron-rich scaffold integrates readily into pharmaceutical intermediates, offering favorable reactivity in transition-metal-catalyzed coupling reactions.

Application

5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-donating methoxy group enhances reactivity in electrophilic substitution, while the primary amine facilitates conjugation and derivatization. The compound exhibits good bench stability and compatibility with standard coupling and protection protocols, making it well-suited for iterative synthesis workflows.

Synthesis

  • Route1
    • 1,2,3,4-Tetrahydro-5-methoxy-N-(phenylmethyl)-2-naphthalenamine|CS-0751337
      136247-07-9
    • ~%
    • In-stock
      5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine|CS-0199121
      4018-91-1

    References

    • Copinga, Swier; Tepper, Pieter G.; Grol, Cor J.; Horn, Alan S.; Dubocovich, Margarita L. Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2891 - 2898
  • Route2
    • In-stock
      5-Methoxyl-2-tetralone|CS-B0110
      32940-15-1
    • null|null
      107-06-2
    • ~%
    • In-stock
      5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine|CS-0199121
      4018-91-1

    References

    • Dr. Karl Thomae GmbH Patent: US4584293 A1, 1986 ;
  • Route3

    References

    • van Vliet; Tepper; Dijkstra; Damsma; Wikstroem; Pugsley; Akunne; Heffner; Glase; Wise Journal of medicinal chemistry, 1996 , vol. 39, # 21 p. 4233 - 4237

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.5112
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4018-91-1 sigma4018-91-1 manufacturer4018-91-1 price4018-91-1 structure4018-91-1 SDSbuy 4018-91-14018-91-1 supplier4018-91-1 uses4018-91-1 molecular weightprice of 4018-91-14018-91-1 chemical name formula of 4018-91-1
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label